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KMID : 0984720080400010049
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Infection and Chemotherapy
2008 Volume.40 No. 1 p.49 ~ p.51
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In Vitro Susceptibility of piperacillin/tazobactam Against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae
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Kim Eui-Chong
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Abstract
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Minimal inhibitory concentrations (MIC) of piperacillin/tazobactam were determined on 20 clinical isolates of extended-spectrum β-lactamase (ESBL)-producing E. coli and 30 isolates of ESBL- producing Klebsiella pneumoniae. MIC50 and MIC90 for ESBL-producing E. coli were 8/4 μg/ml and 256/4 μg/mL, respectively. MIC50 and MIC90 for ESBL-producing K. pneumoniae were 8/4 μg/mL and ＞512/4 μg/mL, respectively. The susceptibilities of ESBL-producing E. coli and K. pneumoniae to piperacillin/tazobactam were 80% and 60%, respectively. Of 20 ESBL-producing E. coli strains, 11 (55%) were TEM-and CTX-M-positive, and SHV-negative. Of 30 ESBL-producing K. pneumoniae strains, ten (33%) were PCR positive for SHV and negative for TEM and CTX-M.
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KEYWORD
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Piperacillin/tazobactam, ESBL-producing E, coli, ESBL-producing K, pneumoniae
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